Microplates: Factors such as plate design, material, manufacturer consistency, and various other physical features affect seal quality. Be sure to only use microplates that are SBS compliant. Here are some other factors to consider when selecting a compatible microplate for thermal sealing.
- Raised rims around each well typically produce the best results, though they are not required.
- Skirtless and half-skirt PCR plates require plate supports.
- Polypropylene microplates offer the most effect and reliable heat seal, though we offer other heat seals that are designed to be compatible with specific polymer substrates such as polystyrene and COC.
- Avoid acrylic microplates because they are not compatible with thermal microplate sealing (See Adhesive Seals for sealing onto acrylic plates).
Seals: Films or foils are welded to microplates using heat sealers to produce a secure seal, normally to raised rims around the individual wells of the microplate. Heat seals are available in carefully tested materials that are suitable for peeling, piercing, storage, transport, and temporary or long-term sealing. Seals that can withstand sub-zero or high temperatures are also available.